As a typical experimental science, the predictability in the field of biotechnology is quite low. In patent examination, there are often some disputes over the predictability of technical effects. For example, the examiner may hold that the technical effects of the invention are unpredictable and the claims cannot be supported by the specification. Or, on the contrary, when there are only theoretical teachings or only general technical demand without specific technical questions, the examiner may believe that the prior art provides a motivation and the technical effect can be reasonably expected. However, this relatively subjective opinion cannot be successfully rebutted without solid evidence. The following are just a few examples to illustrate the above situation.
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